Question of the Day

Study for the USMLE Step 2, daily.

[get_sheet_value location=”Sheet1″]

USMLE Step 2 Question of the Day

January 30, 2023

A 45-year-old man with a history of diabetes mellitus and gallstones comes to his doctor because of a recent 4.5-kg weight loss and fatty stools. Laboratory studies show decreased levels of pepsinogen, amylase, lipase, Insulin, and glucagon. A CT scan shows a mass in the pancreas. Based on this patient’s symptoms, which of the following substances might be secreted by this pancreatic tumor?

Correct Answer: 

E. Somatostatin

Explanation:

Somatostatin is an inhibitory hormone that is normally produced by D cells of the pancreas and inhibits gastric acid, pepsinogen, insulin, glucagon, pancreatic and small intestine fluid release, and gallbladder contraction. Somatostatin secretion is induced by amino acids, free fatty acids, glucose, glucagon, and cholinergic and beta-adrenergic neurotransmitters. It is inhibited by alpha-adrenergic neurotransmitters and insulin. Somatostatin secreting tumors commonly present with a triad of steatorrhea, diabetes mellitus, and gallstones. These tumors are most commonly found in the pancreas but can also be found in the small intestine.

Quick Concepts:

  • Somatostatin
    • Inhibitory hormone
    • Inhibits gastric acid, pepsinogen, insulin, and glucagon
    • Decreases gall bladder contraction

Summary:

Somatostatin is an inhibitory hormone that is normally produced by D cells of the pancreas and inhibits gastric acid, pepsinogen, insulin, and glucagon. Somatostatin secreting tumors commonly present with a triad of steatorrhea, diabetes mellitus, and gallstones.

Correct Answer: 

E. Somatostatin

Explanation:

Somatostatin is an inhibitory hormone that is normally produced by D cells of the pancreas and inhibits gastric acid, pepsinogen, insulin, glucagon, pancreatic and small intestine fluid release, and gallbladder contraction. Somatostatin secretion is induced by amino acids, free fatty acids, glucose, glucagon, and cholinergic and beta-adrenergic neurotransmitters. It is inhibited by alpha-adrenergic neurotransmitters and insulin. Somatostatin secreting tumors commonly present with a triad of steatorrhea, diabetes mellitus, and gallstones. These tumors are most commonly found in the pancreas but can also be found in the small intestine.

Quick Concepts:

  • Somatostatin
    • Inhibitory hormone
    • Inhibits gastric acid, pepsinogen, insulin, and glucagon
    • Decreases gall bladder contraction

Summary:

Somatostatin is an inhibitory hormone that is normally produced by D cells of the pancreas and inhibits gastric acid, pepsinogen, insulin, and glucagon. Somatostatin secreting tumors commonly present with a triad of steatorrhea, diabetes mellitus, and gallstones.


Step 2 Questions

Sign up for Step 2 Emails