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July 22, 2024

Three days after recovering from the “flu”, a 35-year-old woman experiences numbness and tingling of the lower limbs. Over the following day, the numbness becomes accompanied by weakness and spreads to the upper extremities. Which of the following test results will confirm the presumptive diagnosis?

Correct Answer: 

D. Lumbar puncture with albuminocytologic dissociation

Explanation:

The patient’s history is most consistent with Guillain-Barre syndrome (GBS), an autoimmune response activated by an infection. The hallmark finding in GBS is albuminocytologic dissociation. The source of the increased protein count is the autoantibodies in the CSF.

Quick Concepts:

  • GBS lumbar puncture
    • Albuminocytologic dissociation
    • Increased protein levels
    • Normal WBC count

Summary:

Guillain-Barre syndrome (GBS) is an autoimmune response activated by an infection. The hallmark finding in GBS is albuminocytologic dissociation in the CSF fluid. The source of the increased protein count is the autoantibodies in the CSF.

Explanation:



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